About Vyvanse
Vyvanse (lisdexamfetamine dimesylate) is a prescription central nervous system stimulant that is FDA-approved for ADHD in children (aged 6 and older) and adults, and for moderate-to-severe binge eating disorder (BED) in adults — the only ADHD stimulant with this second approval. Made by Takeda Pharmaceuticals, Vyvanse is a prodrug, meaning it is pharmacologically inactive until the body converts it to dextroamphetamine through enzymatic activity in red blood cells. This design provides a smooth, gradual onset and extended duration of 10-14 hours, and significantly reduces the potential for abuse compared to traditional amphetamines since it cannot be crushed and snorted to get an immediate rush.
How It Works
After ingestion, lisdexamfetamine is hydrolyzed (broken down) in the bloodstream to produce active dextroamphetamine. This gradual conversion results in a steady increase in dopamine and norepinephrine levels in the brain, improving attention, impulse control, and executive function in ADHD. The smooth pharmacokinetic profile means fewer peaks and crashes compared to immediate-release stimulants.
Key Facts
- ✓Prodrug design: converts to dextroamphetamine in the body
- ✓Duration: 10-14 hours — longest among common ADHD stimulants
- ✓Schedule II controlled substance
- ✓Generic (lisdexamfetamine) now available as of 2023
- ✓Also FDA-approved for binge eating disorder (BED) in adults
- ✓Lower abuse potential than traditional amphetamines due to prodrug design
Who Is Vyvanse For?
Vyvanse is prescribed for children aged 6 and older and adults with ADHD who need all-day symptom control. It is also prescribed for adults with moderate-to-severe binge eating disorder. It is not appropriate for people with heart disease, structural heart abnormalities, hyperthyroidism, glaucoma, or history of substance abuse. The long duration makes it particularly suitable for students, professionals, and others needing focus throughout a full work or school day.
Snapshot
Cost
Estimated monthly cost:
Medical Disclaimer: This information is for educational purposes only and should not be used as a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any medication. Prices shown are estimates and may vary by location and pharmacy.